Professor Jonathan Lamb returned to Imperial College in 2009 to the Chair of Immunoregulation in the Division of Cell and Molecular Biology, having previously been the Professor of Immunology at St Mary’s Hospital Medical School/Department of Biology at Imperial College from 1990 to 1997. During the interim period he was the Professor of Respiratory Science at Edinburgh University and Head of UK Human Biomarker Laboratory, GlaxoSmithKline, Addenbrooke’s Hospital, Cambridge. Following undergraduate degrees at Edinburgh and Oxford Universities he completed his PhD in immunology in 1980 at London University. Jonathan has been a scientific board member for a number of organizations including the Medical Research Council, World Health Organization, and ARC (Australian Research Council) and is currently a member of the Biotechnology and Biological Sciences Research Council pool of experts. Professor Lamb’s research interests focus on the regulation of inflammatory responses, in particular how the host deciphers and integrates internal and external signals that determine the outcome of protective and pathogenic immunity. Understanding the underlying mechanisms that lead to inappropriate immune responses has potential applications in the longer-term by contributing to the development of new treatments of a variety of diseases. In order to address these scientific questions, he is using zebrafish to model mammalian disease phenotypes and to study host inflammatory responses in real-time from the molecular to whole organism level.